Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 300
interventional 218
Observational 76
Registry 6

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 88
Drug|placebo 38
Device 31
Procedure 11
Drug|Other 8
Other 8
Biological 7
Behavioral 4
Dietary Supplement 4
Biological|placebo 3
Device|Other 3
Dietary Supplement|Drug|placebo 2
Drug|Procedure 2
Behavioral|Other 1
Biological|Drug 1
Biological|Other 1
Device|Dietary Supplement|Other 1
Device|Drug 1
Device|Procedure 1
Diagnostic Test|Drug 1
Dietary Supplement|Drug 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 108
NA 14
China 9
Canada 6
Sweden 6
Korea, Republic of 5
United Kingdom 5
Brazil 4
France 4
Israel 4
Australia 3
Austria 3
Denmark 3
Mexico 3
Norway 3
Spain 3
Taiwan 2
United States|Germany|Italy 2
Armenia|Austria|France|Germany|Greece|Italy|Poland|Spain|United Kingdom 1
Armenia|Austria|France|Germany|Italy|Spain 1
Australia|Belgium|France|Germany|Italy|Russian Federation|Spain|United Kingdom 1
Australia|New Zealand 1
Austria|Czech Republic|Germany|Italy|United Kingdom 1
Belgium 1
Belgium|Netherlands 1
Czechia|France|Italy|Poland|Russian Federation|Spain|Turkey 1
Egypt 1
Estonia|Germany|Italy|Portugal|Slovakia|Spain 1
France|Germany|Spain 1
Germany 1
Greece 1
Iran, Islamic Republic of 1
Italy 1
Japan 1
Japan|Korea, Republic of 1
Poland 1
Singapore 1
Switzerland 1
Thailand 1
United States|Australia 1
United States|Australia|Austria|Belgium|Czechia|France|Germany|Israel|Korea, Republic of|Malaysia|Netherlands|Portugal|Spain|Sweden|Switzerland|Taiwan 1
United States|Belgium 1
United States|Belgium|Canada|France 1
United States|Belgium|Canada|France|Germany|Netherlands|United Kingdom 1
United States|Brazil|Hungary|Italy|Netherlands|Puerto Rico|Spain|United Kingdom 1
United States|Canada|Germany|Italy|Spain 1
United States|Germany|Italy|United Kingdom 1
United States|Puerto Rico 1
United States|Spain|United Kingdom 1

Sites per Study

Site_count Study_Count
1 134
2 9
3 13
4 6
5 6
6 4
7 2
9 5
10 1
11 3
12 2
13 4
14 5
15 2
16 3
17 1
20 1
21 2
22 1
23 2
26 1
27 1
28 1
31 1
40 1
41 1
45 2
60 1
62 1
76 1
91 1

Phase

Phase Study_Count
N/A 69
Phase 2 44
Phase 3 41
Phase 4 26
Phase 1/Phase 2 15
Phase 1 11
Phase 2/Phase 3 8
Early Phase 1 4

Number of Arms

Number_of_Arms Count_of_Studies
1 39
2 109
3 23
4 26
5 4
6 2
8 1
NA 14

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 3.0 2.000 5.0 5.0 4.0000 25.00 10.0000 5.00000
1st Qu. 6.0 29.000 19.5 16.0 60.0000 82.50 90.0000 40.00000
Median 29.5 48.000 24.0 27.0 113.0000 111.50 332.0000 51.00000
Mean 31.5 710.942 30.0 36.4 147.1364 174.50 555.3902 73.38462
3rd Qu. 55.0 128.000 44.5 37.5 187.2500 258.25 588.0000 67.50000
Max. 64.0 25875.000 57.0 120.0 722.0000 455.00 4757.0000 334.00000

Trial Group Type

group_type Group_Count
Experimental 246
Active Comparator 109
Placebo Comparator 76
Other 15
NA 14
No Intervention 13
Sham Comparator 11

Intervention Model

intervention_model Study_Count
Parallel Assignment 150
Single Group Assignment 48
Crossover Assignment 9
Factorial Assignment 5
Sequential Assignment 4
NA 2

Primary Purpose

primary_purpose Study_Count
Treatment 177
Diagnostic 9
Supportive Care 7
Prevention 6
Other 5
Basic Science 4
NA 4
Screening 3
Health Services Research 2
Device Feasibility 1

Observational Studies

Studies by Country

Country Study_Count
United States 32
NA 9
China 8
France 4
United Kingdom 3
Germany 2
Italy 2
Taiwan 2
Brazil 1
Canada 1
Canada|United Kingdom 1
Denmark 1
Egypt 1
Iran, Islamic Republic of 1
Norway 1
Poland 1
Switzerland 1
United States|Belgium|Brazil|Canada|France|Germany|Israel|Netherlands|Poland|United Kingdom 1
United States|China|India|Iran, Islamic Republic of|Italy|Pakistan|Philippines|Ukraine 1
United States|France|Germany|Netherlands 1
United States|France|Germany|Spain|United Kingdom 1
United States|United Kingdom 1

Sites per Study

Site_count Study_Count
1 61
2 8
4 1
5 1
6 1
7 1
10 1
11 1
26 1

Enrollment Metrics

Measure Observational
Min 2.00
1st Qu 60.00
Median 219.50
Mean 28388.17
3rd Qu 603.75
Max 1800000.00

Observation Model

observational_model Study_Count
Cohort 32
NA 16
Case-Control 11
Case-Only 10
Case Control 3
Other 3
Case-Crossover 1

Time Perspective

time_perspective Study_Count
Prospective 46
Cross-Sectional 12
NA 10
Other 4
Retrospective 4

Registries

Studies by Country

Country Study_Count
China 2
United States 2
Portugal 1
United Kingdom 1

Sites per Study

Site_count Study_Count
1 5
2 1

Enrollment Metrics

Measure Registries
Min 100.0
1st Qu 679.5
Median 1156.5
Mean 3337174.7
3rd Qu 15375.0
Max 20000000.0

Registry Model

observational_model Study_Count
Cohort 4
Other 2

Time Perspective

time_perspective Study_Count
Prospective 5
Other 1

Follow-up

target_duration Study_Count
1 Day 1
1 Month 1
1 Year 1
10 Years 1
20 Years 1
3 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04460001 Injection of Ranibizumab Versus Combination of Ranibizumab and Triamcinolone Acetate for (CRVO) https://ClinicalTrials.gov/show/NCT04460001 Recruiting Assiut University 2021-08-01
NCT04457648 Manuka Honey Eye Drops VS Conventional Treatment of Meibomian Gland Dysfunction Related Dry Eye Disease https://ClinicalTrials.gov/show/NCT04457648 Completed Chinese University of Hong Kong 2020-06-01
NCT04393441 Efficacy and Safety of a New Artificial Tear Formulation Compared With Systane Ultra Multidose in Participants With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04393441 Recruiting Allergan 2020-11-27
NCT04387292 Ocular Sequelae of Patients Hospitalized for Respiratory Failure During the COVID-19 Epidemic https://ClinicalTrials.gov/show/NCT04387292 Recruiting Fondation Ophtalmologique Adolphe de Rothschild 2021-05-31
NCT03333057 Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03333057 Completed Novaliq GmbH 2018-05-18
NCT03332342 Closed Eye Neutrophils in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03332342 Completed University of Alabama at Birmingham 2018-12-12
NCT03302273 Corneal Epithelial Stem Cells and Dry Eye Disease https://ClinicalTrials.gov/show/NCT03302273 Enrolling by invitation Panhandle Eye Group, LLP 2021-02-01
NCT03298867 Treatment of Graves’ Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study https://ClinicalTrials.gov/show/NCT03298867 Active, not recruiting Horizon Pharma USA, Inc. 2019-02-13
NCT03292809 CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03292809 Completed Novaliq GmbH 2018-05-22
NCT03287635 Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03287635 Recruiting Toyos Clinic 2020-05-31
NCT03278964 Analysis Between the Results of Two Surgical Techniques of Orbital Decompression in Patients With Graves Orbitopathy https://ClinicalTrials.gov/show/NCT03278964 Completed University of Sao Paulo General Hospital 2019-01-31
NCT03265652 IPL and MGX Versus MGX Alone in the Treatment of Dry Eye Disease Secondary to MGD https://ClinicalTrials.gov/show/NCT03265652 Completed Lumenis Ltd. 2019-04-18
NCT03216096 Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03216096 Completed Santen Pharmaceutical Co., Ltd. 2018-02-01
NCT03201588 Multi-Center Study to Determine the Role of Fatty Acids in Serum in Preventing Retinopathy of Prematurity (MDM) https://ClinicalTrials.gov/show/NCT03201588 Completed Göteborg University 2019-11-15
NCT03148132 VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP https://ClinicalTrials.gov/show/NCT03148132 Completed Universidad Autonoma de San Luis Potosí 2018-08-30
NCT03131726 Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS) https://ClinicalTrials.gov/show/NCT03131726 Recruiting Lund University 2020-01-26
NCT03127163 Intraestromal Corneal Ring in Mild Keratoconus https://ClinicalTrials.gov/show/NCT03127163 Completed University of Sao Paulo 2016-01-10
NCT03108664 HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03108664 Completed Sylentis, S.A. 2018-10-16
NCT03107078 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial https://ClinicalTrials.gov/show/NCT03107078 Recruiting The Third Affiliated Hospital of Southern Medical University 2019-10-01
NCT03080714 Triton Agreement and Precision Study https://ClinicalTrials.gov/show/NCT03080714 Completed Topcon Medical Systems, Inc. 2017-08-30
NCT03052140 Lamelleye vs Comparator for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT03052140 Completed Glasgow Caledonian University 2017-08-09
NCT03048526 Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease https://ClinicalTrials.gov/show/NCT03048526 Completed Novaliq GmbH 2017-04-18
NCT02980224 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02980224 Completed OmegaD LLC 2017-02-28
NCT02967614 KJ-TFC-004 Drug-drug Interaction Study https://ClinicalTrials.gov/show/NCT02967614 Completed Kukje Pharma 2017-12-31
NCT02848222 Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers https://ClinicalTrials.gov/show/NCT02848222 Completed University of Alabama at Birmingham 2017-12-31
NCT02845336 Celecoxib for Thyroid Eye Disease https://ClinicalTrials.gov/show/NCT02845336 Recruiting Johns Hopkins University 2020-07-31
NCT02823600 Feasibility Study of Retinal Screening Using the RetinaVue 100 Camera in Outpatient Dialysis Centers https://ClinicalTrials.gov/show/NCT02823600 Completed University of North Carolina, Chapel Hill 2017-05-31
NCT02819284 Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02819284 Completed Kala Pharmaceuticals, Inc. 2017-09-30
NCT02813265 Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02813265 Completed Kala Pharmaceuticals, Inc. 2017-10-31
NCT02764814 In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye https://ClinicalTrials.gov/show/NCT02764814 Completed Tissue Tech Inc. 2016-09-30
NCT02710916 SD-OCT Multimodal Analysis in GLaucoma https://ClinicalTrials.gov/show/NCT02710916 Completed University Hospital, Bordeaux 2018-12-21
NCT02693808 New Treatment for Patients With Temporal Hollowing After Lateral Wall Decompression https://ClinicalTrials.gov/show/NCT02693808 Completed Haukeland University Hospital 2018-01-31
NCT02665234 A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02665234 Completed Mimetogen Pharmaceuticals USA, Inc. 2017-02-28
NCT02617667 CyclASol for the Treatment of Moderate to Severe Dry-eye Disease (DED) https://ClinicalTrials.gov/show/NCT02617667 Completed Novaliq GmbH 2016-07-31
NCT03404115 A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03404115 Completed Aldeyra Therapeutics, Inc. 2018-07-11
NCT02554084 Optical Coherence Tomography of Tear Film Dynamics In-Vivo https://ClinicalTrials.gov/show/NCT02554084 Completed University of Rochester 2017-09-30
NCT02553772 A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease. https://ClinicalTrials.gov/show/NCT02553772 Completed Allergan 2016-09-09
NCT02543229 Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentisâ„¢ in Patients With Wet AMD https://ClinicalTrials.gov/show/NCT02543229 Completed Opthea Limited 2017-02-07
NCT02535975 The Effects of Metformin in Patients With Mild Graves’ Ophthalmopathy https://ClinicalTrials.gov/show/NCT02535975 Recruiting Yonsei University 2019-10-31
NCT02459782 Ultrasound Guided Peribulbar Anaesthesia - A Novel Dual Quadrant Injection Technique https://ClinicalTrials.gov/show/NCT02459782 Completed Sunnybrook Health Sciences Centre 2012-03-31
NCT02417116 Tear Osmolarity Clinical Utility in Dry Eye Disease https://ClinicalTrials.gov/show/NCT02417116 Completed Aston University 2019-01-31
NCT02393183 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) https://ClinicalTrials.gov/show/NCT02393183 Recruiting Iran University of Medical Sciences 2022-06-15
NCT02378298 Rituximab (RTX) Therapy in Patients With Active TAO https://ClinicalTrials.gov/show/NCT02378298 Recruiting Göteborg University 2019-05-31
NCT02365519 LME636 in the Relief of Persistent Ocular Discomfort in Subjects With Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT02365519 Completed Alcon Research 2015-10-16
NCT02359149 Intravitreal Injections by Nurses and Physicians Compared https://ClinicalTrials.gov/show/NCT02359149 Completed St. Olavs Hospital 2017-03-31
NCT02284516 A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) https://ClinicalTrials.gov/show/NCT02284516 Completed Shire 2015-10-05
NCT02260960 The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02260960 Completed Physician Recommended Nutriceuticals 2015-03-31
NCT02254265 Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Sicca https://ClinicalTrials.gov/show/NCT02254265 Completed Sun Pharma Global FZE 2015-05-31
NCT02242032 Study of the Safety and Tolerability of P 321 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02242032 Completed Parion Sciences 2015-03-31
NCT02229955 Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Comparisons for Evaluation of Efficacy and Safety in Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT02229955 Completed Hanlim Pharm. Co., Ltd. 2014-04-30
NCT02188160 Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT02188160 Completed Kala Pharmaceuticals, Inc. 2015-01-31
NCT02157077 Aflibercept After Ranibizumab in Exudative Age-related Macular Degeneration https://ClinicalTrials.gov/show/NCT02157077 Completed Centre Hospitalier Intercommunal Creteil 2015-12-31
NCT02155049 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues https://ClinicalTrials.gov/show/NCT02155049 Completed Rabin Medical Center 2017-05-31
NCT02136940 Multiple Dose-parallel-group Study of AMA0076 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension https://ClinicalTrials.gov/show/NCT02136940 Completed Amakem, NV 2014-11-30
NCT02120079 The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patients With DED https://ClinicalTrials.gov/show/NCT02120079 Completed Tufts Medical Center 2017-04-30
NCT02089009 Comparison of Non-mydriatic Camera Systems in a Female Health Hospital https://ClinicalTrials.gov/show/NCT02089009 Completed University Hospital Tuebingen 2016-02-29
NCT02059655 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) https://ClinicalTrials.gov/show/NCT02059655 Completed Cardiff University 2016-03-31
NCT01297699 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) https://ClinicalTrials.gov/show/NCT01297699 Completed Hospital Clinico Universitario de Santiago 2015-10-31
NCT01276223 Evaluation of Anti-Inflammatory Treatment in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01276223 Completed Alcon Research 2012-01-31
NCT02051023 Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca) https://ClinicalTrials.gov/show/NCT02051023 Completed Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA 2014-12-31
NCT04005352 Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON) https://ClinicalTrials.gov/show/NCT04005352 Recruiting Novartis 2022-01-31
NCT03785340 Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03785340 Completed Ocugen 2019-02-28
NCT02004067 Safety Study of the Use of Topical Cyclosporine in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT02004067 Completed Federal University of São Paulo 2016-08-31
NCT02001129 Improving Follow-Up Adherence in a Primary Eye Care Setting https://ClinicalTrials.gov/show/NCT02001129 Completed Wills Eye 2014-02-28
NCT01998802 Phase 3 Study of EBI-005 in Dry Eye Disease https://ClinicalTrials.gov/show/NCT01998802 Completed Eleven Biotherapeutics 2015-03-31
NCT04426331 Vouchers to Increase Uptake of Already Free Eye Care https://ClinicalTrials.gov/show/NCT04426331 Completed Johns Hopkins University 2019-01-01
NCT01880463 Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL) https://ClinicalTrials.gov/show/NCT01880463 Active, not recruiting Brigham and Women’s Hospital 2020-12-31
NCT01868997 Teprotumumab (RV 001) Treatment in Patients With Active Thyroid Eye Disease https://ClinicalTrials.gov/show/NCT01868997 Completed Horizon Pharma USA, Inc. 2016-03-31
NCT01817582 Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease) https://ClinicalTrials.gov/show/NCT01817582 Completed Bausch & Lomb Incorporated 2014-01-10
NCT01798966 Twenty-four Hour Intraocular Pressure Patterns in Patients With Uncontrolled Thyroid Eye Disease https://ClinicalTrials.gov/show/NCT01798966 Completed Sensimed AG 2013-06-30
NCT01775540 Systane Ultra Versus Maxidex Versus Saline https://ClinicalTrials.gov/show/NCT01775540 Completed Icahn School of Medicine at Mount Sinai 2012-10-31
NCT01743729 A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT01743729 Completed Shire 2013-10-01
NCT01738243 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease https://ClinicalTrials.gov/show/NCT01738243 Recruiting University of California, Los Angeles 2021-03-31
NCT01727973 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves’ Orbitopathy https://ClinicalTrials.gov/show/NCT01727973 Completed Sun Yat-sen University 2013-11-30
NCT01693315 Multiple Dose-escalation Study of AMA0076 in Patients With Ocular Hypertension or Primary Open-angle Glaucoma https://ClinicalTrials.gov/show/NCT01693315 Completed Amakem, NV 2013-07-31
NCT04125134 Predicting the Success of Dry Eye Disease Interventions Using Clinical Tests https://ClinicalTrials.gov/show/NCT04125134 Recruiting Tufts Medical Center 2020-05-31
NCT01675570 A Study of RX-10045 in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT01675570 Completed C.T. Development America, Inc. 2012-11-30
NCT01664949 A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVEâ„¢ in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01664949 Completed Allergan 2014-05-31
NCT01650584 Evaluation of Ocular Comfort With ISTA Tears vs Systane https://ClinicalTrials.gov/show/NCT01650584 Completed Bausch & Lomb Incorporated 2012-12-31
NCT01648452 CNTF Implants for CNGB3 Achromatopsia https://ClinicalTrials.gov/show/NCT01648452 Completed National Institutes of Health Clinical Center (CC) 2013-03-31
NCT01636206 Safety Study of Lifitegrast to Treat Dry Eye https://ClinicalTrials.gov/show/NCT01636206 Completed Shire 2014-03-03
NCT01599273 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections https://ClinicalTrials.gov/show/NCT01599273 Completed Yonsei University 2014-08-31
NCT01579539 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy https://ClinicalTrials.gov/show/NCT01579539 Completed Medical University of Vienna 2017-05-18
NCT01562795 Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT01562795 Completed Wenzhou Medical University 2012-06-30
NCT01494805 Safety and Efficacy Study of rAAV.sFlt-1 in Patients With Exudative Age-Related Macular Degeneration https://ClinicalTrials.gov/show/NCT01494805 Completed Lions Eye Institute, Perth, Western Australia 2017-05-31
NCT01468168 A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients https://ClinicalTrials.gov/show/NCT01468168 Completed Santen Inc. 2012-11-30
NCT01458600 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) https://ClinicalTrials.gov/show/NCT01458600 Completed Region Skane 2016-02-29
NCT01421498 Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1) https://ClinicalTrials.gov/show/NCT01421498 Completed Shire 2012-04-28
NCT01399515 Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa https://ClinicalTrials.gov/show/NCT01399515 Completed Seoul National University Hospital 2013-08-31
NCT04425551 Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction https://ClinicalTrials.gov/show/NCT04425551 Active, not recruiting Naval Hospital, Athens 2020-09-30
NCT04362670 Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease. https://ClinicalTrials.gov/show/NCT04362670 Active, not recruiting Ocular Therapeutix, Inc. 2020-11-30
NCT04271709 Manhattan Vision Screening and Follow-Up Study https://ClinicalTrials.gov/show/NCT04271709 Recruiting Columbia University 2024-09-30
NCT04268069 Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye https://ClinicalTrials.gov/show/NCT04268069 Recruiting ORA, Inc. 2020-07-31
NCT04202562 Efficacy and Safety of ab Interno Trabeculectomy With the Kahook Dual Blade https://ClinicalTrials.gov/show/NCT04202562 Completed Hospital San Carlos, Madrid 2017-11-29
NCT04201574 Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04201574 Recruiting Allysta Pharmaceutical 2020-08-31
NCT04181593 Phase 3 Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT04181593 Recruiting OmegaD LLC 2020-07-31
NCT04159935 Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease https://ClinicalTrials.gov/show/NCT04159935 Recruiting University of Waterloo 2020-06-30
NCT04144413 3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin) https://ClinicalTrials.gov/show/NCT04144413 Recruiting Santen SAS 2023-05-31
NCT04143841 Viveye Ocular Magnetic Neurostimulation System (OMNS) for the Management of Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04143841 Recruiting Epitech Mag Ltd. 2020-10-31
NCT04123626 A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene https://ClinicalTrials.gov/show/NCT04123626 Recruiting ProQR Therapeutics 2021-10-07
NCT04120584 Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction https://ClinicalTrials.gov/show/NCT04120584 Recruiting InMode MD Ltd. 2020-10-31
NCT04115800 Liposomal Sirolimus in Dry Eye Disease https://ClinicalTrials.gov/show/NCT04115800 Recruiting Instituto de Oftalmología Fundación Conde de Valenciana 2020-05-01
NCT04105842 Refitting Daily Disposable Contact Lens Wearers With Dry Eye Disease With A Different Daily Disposable Lens Type https://ClinicalTrials.gov/show/NCT04105842 Recruiting University of Waterloo 2020-02-28
NCT04096898 Senofilcon A Lenses in Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04096898 Recruiting University of Illinois at Chicago 2020-12-31
NCT04084483 A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT04084483 Completed Kowa Research Institute, Inc. 2020-01-03
NCT04073238 Efficacy of Repeated Low-Level Red-Light Therapy in Myopia Control https://ClinicalTrials.gov/show/NCT04073238 Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University 2020-12-31
NCT04036292 Clinical Trial to Evaluate the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-2 Study) https://ClinicalTrials.gov/show/NCT04036292 Active, not recruiting Oyster Point Pharma, Inc. 2020-05-08
NCT04015219 Management of Signs and Symptoms Associated With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04015219 Recruiting Tissue Tech Inc. 2020-07-01
NCT03992482 IVIG-eye Drops Treatment for Dry Eye Disease https://ClinicalTrials.gov/show/NCT03992482 Completed University of Illinois at Chicago 2019-08-02
NCT03990506 Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus https://ClinicalTrials.gov/show/NCT03990506 Recruiting Umeå University 2021-06-02
NCT03987880 Photorefractive Intrastromal Corneal Crosslinking as a Treatment for Low Grade Myopia https://ClinicalTrials.gov/show/NCT03987880 Active, not recruiting Umeå University 2020-03-22
NCT03956225 Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study https://ClinicalTrials.gov/show/NCT03956225 Active, not recruiting Alcon Research 2020-10-31
NCT03954626 Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD https://ClinicalTrials.gov/show/NCT03954626 Completed Novartis 2019-07-09
NCT03948191 99Tc-MDP for Thyroid-Associated Ophthalmopathy https://ClinicalTrials.gov/show/NCT03948191 Completed Dalian University 2018-12-30
NCT03938545 ASCEND GO-2: Study of RVT-1401 for the Treatment of Patients With Active, Moderate to Severe Graves’ Ophthalmopathy ( GO ) https://ClinicalTrials.gov/show/NCT03938545 Recruiting Immunovant Sciences GmbH 2021-01-31
NCT03922321 Study of RVT-1401 for the Treatment of Patients With Moderate to Severe Active Graves’ Ophthalmopathy ( GO ) https://ClinicalTrials.gov/show/NCT03922321 Active, not recruiting Immunovant Sciences GmbH 2020-03-31
NCT03920215 Clinical Trial to Evaluate the Long Term Follow up of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET Study) https://ClinicalTrials.gov/show/NCT03920215 Completed Oyster Point Pharma, Inc. 2019-10-12
NCT03916042 A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Clinical Trial of Reproxalap to Assess the Safety and Efficacy in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03916042 Active, not recruiting Aldeyra Therapeutics, Inc. 2020-04-30
NCT03913143 A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE) https://ClinicalTrials.gov/show/NCT03913143 Recruiting ProQR Therapeutics 2020-12-31
NCT03913130 Extension Study to Study PQ-110-001 (NCT03140969) https://ClinicalTrials.gov/show/NCT03913130 Active, not recruiting ProQR Therapeutics 2021-03-31
NCT03907865 Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation https://ClinicalTrials.gov/show/NCT03907865 Completed Medical University of Vienna 2018-11-28
NCT03888183 Effect of Preservative-free Low-dose Hyaluronic Acid-containing Salt Solution on Dry Eye Disease https://ClinicalTrials.gov/show/NCT03888183 Recruiting Chang Gung Memorial Hospital 2020-01-22
NCT03879863 The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03879863 Active, not recruiting Aldeyra Therapeutics, Inc. 2021-04-30
NCT03873246 Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC Study) https://ClinicalTrials.gov/show/NCT03873246 Completed Oyster Point Pharma, Inc. 2020-01-07
NCT03872479 Single Ascending Dose Study in Participants With LCA10 https://ClinicalTrials.gov/show/NCT03872479 Recruiting Allergan 2024-03-22
NCT03857919 TearCare System to Treat Dry Eye Disease https://ClinicalTrials.gov/show/NCT03857919 Recruiting Sight Sciences, Inc. 2019-10-31
NCT03833882 Evaluation of MAF-1217 in Patients With DED https://ClinicalTrials.gov/show/NCT03833882 Completed VISUfarma SpA 2019-06-19
NCT03827564 Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03827564 Recruiting Allergan 2020-06-30
NCT03766737 Validation of the Utility of an Intelligent Visual Acuity Diagnostic System for Children https://ClinicalTrials.gov/show/NCT03766737 Completed Sun Yat-sen University 2018-07-20
NCT03766425 Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy. https://ClinicalTrials.gov/show/NCT03766425 Active, not recruiting Medical University of Lublin 2019-07-31
NCT03709641 A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion https://ClinicalTrials.gov/show/NCT03709641 Completed The Eye Care Institute 2018-11-28
NCT03708627 Bimatoprost as a Treatment for Graves’ Orbitopathy https://ClinicalTrials.gov/show/NCT03708627 Recruiting University of Washington 2021-05-31
NCT03706443 Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops https://ClinicalTrials.gov/show/NCT03706443 Completed Ohio State University 2019-02-28
NCT03691636 Eyelash Prostheses Compared to 5.0% Lifitegrast BID for Dry Eye Disease. https://ClinicalTrials.gov/show/NCT03691636 Recruiting D.E.L., LLC 2019-04-02
NCT03688802 Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation (The IMPERIAL Study) https://ClinicalTrials.gov/show/NCT03688802 Completed Oyster Point Pharma, Inc. 2019-09-30
NCT03667157 Liver Function After Intravenous Methylprednisolone Administration https://ClinicalTrials.gov/show/NCT03667157 Completed Medical University of Warsaw 2016-10-30
NCT03660475 Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects https://ClinicalTrials.gov/show/NCT03660475 Completed Total Eye Care, PA 2018-11-01
NCT03658811 Intense Pulse Light Treatment With Meibomian Gland Expression of the Upper Eyelids in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03658811 Completed Toyos Clinic 2018-10-30
NCT03652051 A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03652051 Recruiting Azura Ophthalmics 2020-12-31
NCT03636061 Clinical Trial to Evaluate the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The ONSET-1 Study) https://ClinicalTrials.gov/show/NCT03636061 Completed Oyster Point Pharma, Inc. 2018-09-26
NCT03633461 Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The RAINIER Study) https://ClinicalTrials.gov/show/NCT03633461 Completed Oyster Point Pharma, Inc. 2018-09-20
NCT03598699 A Study to Evaluate the Safety, Tolerability, Systemic Pharmacokinetics, and Pharmacodynamics of AXR-159 Ophthalmic Solution in Patients With Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03598699 Active, not recruiting AxeroVision, Inc. 2019-03-31
NCT03597139 Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03597139 Completed Aurinia Pharmaceuticals Inc. 2018-11-09
NCT03588624 Study of the TearCare System in Dry Eye Disease https://ClinicalTrials.gov/show/NCT03588624 Recruiting Sight Sciences, Inc. 2018-09-30
NCT03580343 Tofacitinib for Inflammatory Eye Disease https://ClinicalTrials.gov/show/NCT03580343 Active, not recruiting Washington University School of Medicine 2019-12-01
NCT03527212 A Study to Assess the Safety and Effectiveness of SJP-0035 for the Treatment of Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03527212 Completed Senju Pharmaceutical Co., Ltd. 2019-03-15
NCT03519815 Clinical Study to Evaluate the Efficacy of Ectoin® Containing Eye Spray for Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT03519815 Completed University of Applied Sciences and Arts Northwestern Switzerland 2018-10-30
NCT03492541 Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT03492541 Completed Alcon Research 2019-04-30
NCT03467490 Self-care Management Program for Dry Eye Disease Patients Using the heiQ https://ClinicalTrials.gov/show/NCT03467490 Active, not recruiting Lawson Health Research Institute 2019-01-19
NCT03452397 Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study) https://ClinicalTrials.gov/show/NCT03452397 Completed Oyster Point Pharma, Inc. 2018-05-16
NCT03418727 Dry Eye Disease Study With Brimonidine https://ClinicalTrials.gov/show/NCT03418727 Completed Ocugen 2018-03-29
NCT03415490 Self-adherent Wrap Techniques for Orbital Surgery https://ClinicalTrials.gov/show/NCT03415490 Completed Sun Yat-sen University 2018-04-21
NCT01239069 Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease https://ClinicalTrials.gov/show/NCT01239069 Completed Santen Inc. 2011-10-31
NCT01235234 Trial of CF101 to Treat Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01235234 Completed Can-Fite BioPharma 2013-11-30
NCT01135511 A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01135511 Completed Pfizer 2011-04-30
NCT03871361 Abatacept in Patients With Birdshot HLA A29 Uveitis https://ClinicalTrials.gov/show/NCT03871361 Recruiting Universitaire Ziekenhuizen Leuven 2020-04-01
NCT01024998 Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD) https://ClinicalTrials.gov/show/NCT01024998 Completed Sanofi 2014-07-31
NCT01016873 INTREPID - IRay Plus Anti-VEGF Treatment For Patients With Wet AMD https://ClinicalTrials.gov/show/NCT01016873 Completed Oraya Therapeutics, Inc. 2012-05-31
NCT01014078 A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT01014078 Completed Merck Sharp & Dohme Corp. 2010-03-31
NCT01003691 Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy https://ClinicalTrials.gov/show/NCT01003691 Completed Pfizer 2013-03-31
NCT00957190 The DIOXXACT Trial(Diurnal IOP and OBF Xalatan vs Xalatan And Cosopt Trial) https://ClinicalTrials.gov/show/NCT00957190 Completed Maisonneuve-Rosemont Hospital 2011-09-14
NCT00954057 Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED) https://ClinicalTrials.gov/show/NCT00954057 Completed Neothetics, Inc 2011-06-30
NCT00913029 Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG) https://ClinicalTrials.gov/show/NCT00913029 Completed Glaukos Corporation 2012-09-30
NCT00911924 A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma https://ClinicalTrials.gov/show/NCT00911924 Completed Glaukos Corporation 2013-09-30
NCT00877032 Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration https://ClinicalTrials.gov/show/NCT00877032 Completed Pfizer 2011-07-31
NCT03878628 Treatment With Allogeneic Adipose-derived Mesenchymal Stem Cells in Patients With Aqueous Deficient Dry Eye Disease https://ClinicalTrials.gov/show/NCT03878628 Recruiting Rigshospitalet, Denmark 2020-04-30
NCT00831662 The Effects of Diquafosol Tetrasodium Ophthalmic Solution, 2% in Subjects With Dry Eye Disease (P08637) https://ClinicalTrials.gov/show/NCT00831662 Completed Merck Sharp & Dohme Corp. 2009-12-31
NCT04150432 Correlation Between Exhaled Propofol Concentration With Plasma Concentration in Children https://ClinicalTrials.gov/show/NCT04150432 Recruiting Oslo University Hospital 2020-06-30
NCT04030962 A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04030962 Recruiting Allergan 2020-09-30
NCT03889886 Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED) https://ClinicalTrials.gov/show/NCT03889886 Active, not recruiting Silk Technologies, Ltd. 2020-01-31
NCT02003547 A Single Centre Study to Evaluate 3 Ophthalmic Formulations in Healthy Subjects https://ClinicalTrials.gov/show/NCT02003547 Completed Amakem, NV 2013-12-31
NCT01746563 Intravitreal Ranibizumab Combined With Panretinal Photocoagulation in Patients With Proliferative Diabetic Retinopathy https://ClinicalTrials.gov/show/NCT01746563 Completed University of Sao Paulo 2012-08-31
NCT03846193 First in Human Study to Evaluate the Safety and Efficacy of GT005 Administered in Subjects With Dry AMD https://ClinicalTrials.gov/show/NCT03846193 Recruiting Gyroscope Therapeutics 2021-06-30
NCT04139122 Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT04139122 Completed Senju Pharmaceutical Co., Ltd. 2020-03-03
NCT04005651 Safety and Efficacy of a Trifocal Intraocular Lens (IOL) POD L GF in Comparison With a Multifocal and a Monofocal IOL https://ClinicalTrials.gov/show/NCT04005651 Recruiting Physiol 2020-06-30
NCT03451396 Effect of Lifitegrast on Dry Eye Disease Signs and Symptoms https://ClinicalTrials.gov/show/NCT03451396 Completed Lifelong Vision Foundation 2018-02-01
NCT03089580 Intense Pulsed Light Study for Dry Eye Disease https://ClinicalTrials.gov/show/NCT03089580 Completed University of Michigan 2018-11-01
NCT02766660 Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy https://ClinicalTrials.gov/show/NCT02766660 Completed Neon Hospital 2013-01-31
NCT02579837 CLEAR SIGHT: A Trial of Non-Mydriatic Ultra-Widefield Retinal Imaging to Screen for Diabetic Eye Disease https://ClinicalTrials.gov/show/NCT02579837 Active, not recruiting Western University, Canada 2020-07-31
NCT03461211 Treatment of Graves’ Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study https://ClinicalTrials.gov/show/NCT03461211 Active, not recruiting Horizon Pharma USA, Inc. 2020-06-08
NCT04096612 The Therapeutic Effect of Dysthyroid Optic Neuropathy https://ClinicalTrials.gov/show/NCT04096612 Recruiting Sun Yat-sen University 2018-12-31
NCT03855462 Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment https://ClinicalTrials.gov/show/NCT03855462 Recruiting University Hospital, Toulouse 2019-09-30
NCT03780257 Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene https://ClinicalTrials.gov/show/NCT03780257 Recruiting ProQR Therapeutics 2021-12-31
NCT00760045 Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time https://ClinicalTrials.gov/show/NCT00760045 Completed Alcon Research 2008-10-31
NCT00758784 Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease https://ClinicalTrials.gov/show/NCT00758784 Completed Bausch & Lomb Incorporated 2009-06-30
NCT00680108 A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution https://ClinicalTrials.gov/show/NCT00680108 Completed Merck Sharp & Dohme Corp. 2000-05-31
NCT00679718 A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease https://ClinicalTrials.gov/show/NCT00679718 Completed Merck Sharp & Dohme Corp. 2000-07-31
NCT00667004 Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease https://ClinicalTrials.gov/show/NCT00667004 Completed Bausch & Lomb Incorporated 2008-12-31
NCT00610480 Effects of Tear Film Stability After Instillation Of OTC Artificial Drops https://ClinicalTrials.gov/show/NCT00610480 Completed University of Texas Southwestern Medical Center 2009-03-31
NCT00600288 Study of the Effect of Diquafosol Tetrasodium Ophthalmic Solution, 2% Versus Placebo in Dry Eye Subjects (P08634) https://ClinicalTrials.gov/show/NCT00600288 Completed Merck Sharp & Dohme Corp. 2008-05-31
NCT00599716 Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome https://ClinicalTrials.gov/show/NCT00599716 Completed Lantibio 2008-04-30
NCT00595335 Trial of Rituximab for Graves’ Ophthalmopathy https://ClinicalTrials.gov/show/NCT00595335 Completed Mayo Clinic 2013-03-31
NCT00591110 Project inCharge: Increasing the Rate of Comprehensive Eye Care Utilization by Older African Americans Through Community-Based Eye Health Education Program https://ClinicalTrials.gov/show/NCT00591110 Completed University of Alabama at Birmingham 2009-03-31
NCT00567177 Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease https://ClinicalTrials.gov/show/NCT00567177 Completed Innovative Medical NA
NCT00520260 Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase https://ClinicalTrials.gov/show/NCT00520260 Completed Florida Eye Microsurgical Institute 2008-08-31
NCT00430547 Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies https://ClinicalTrials.gov/show/NCT00430547 Completed Barwon Health NA
NCT00424151 Rituximab Treatment of Graves’ Dysthyroid Ophthalmopathy https://ClinicalTrials.gov/show/NCT00424151 Completed Silkiss, Rona Z., M.D., FACS 2009-03-31
NCT00799682 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® https://ClinicalTrials.gov/show/NCT00799682 Completed Ophthalmic Consultants of Long Island 2011-01-31
NCT00407043 Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis https://ClinicalTrials.gov/show/NCT00407043 Completed Ophthalmic Consultants of Long Island 2007-09-30
NCT00404131 Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00404131 Completed Merck Sharp & Dohme Corp. 2001-12-31
NCT00403975 Study of Diquafosol Tetrasodium Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00403975 Completed Merck Sharp & Dohme Corp. 2004-11-30
NCT00403715 Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00403715 Completed Merck Sharp & Dohme Corp. 2002-09-30
NCT00395759 The Visual Effect of an Investigational Artificial Tear in the Tear Layer. https://ClinicalTrials.gov/show/NCT00395759 Completed Southern California College of Optometry NA
NCT00386906 Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma https://ClinicalTrials.gov/show/NCT00386906 Active, not recruiting M.D. Anderson Cancer Center 2021-05-31
NCT00348413 Thyroid Treatment Trial https://ClinicalTrials.gov/show/NCT00348413 Completed Singapore National Eye Centre 2008-07-31
NCT00345176 Age-Related Eye Disease Study 2 (AREDS2) https://ClinicalTrials.gov/show/NCT00345176 Completed National Eye Institute (NEI) 2012-10-31
NCT00337298 The Effect of Amlodipine and Lisinopril on Retinal Autoregulation in Type 1 Diabetes https://ClinicalTrials.gov/show/NCT00337298 Completed University of Aarhus 2009-02-28
NCT00333203 Next Generation Ophthalmic Irrigating Solution Posterior Segment Study https://ClinicalTrials.gov/show/NCT00333203 Completed Alcon Research 2006-03-31
NCT00315640 Anecortave Acetate for Treatment of Steroid Induced Intraocular Pressure (IOP) Elevation https://ClinicalTrials.gov/show/NCT00315640 Completed Alcon Research 2009-07-31
NCT00270647 Physicians’ Health Study II https://ClinicalTrials.gov/show/NCT00270647 Completed Brigham and Women’s Hospital 2011-06-30
NCT00211432 Treatment of Pseudovitellium Detachment With Open-Label Anecortave Acetate Sterile Suspension (15 mg) https://ClinicalTrials.gov/show/NCT00211432 Completed Manhattan Eye, Ear & Throat Hospital 2010-04-30
NCT00150111 Rituximab in the Treatment of Graves’ Disease https://ClinicalTrials.gov/show/NCT00150111 Completed Odense University Hospital NA
NCT00123279 Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy https://ClinicalTrials.gov/show/NCT00123279 Completed ThromboGenics 2007-02-28
NCT00120432 Single Dose of 1% Tropicamide and 10% Phenylephrine for Pupillary Dilation https://ClinicalTrials.gov/show/NCT00120432 Completed Khon Kaen University NA
NCT00006422 Evaluation and Treatment of Pediatric Eye Diseases https://ClinicalTrials.gov/show/NCT00006422 Completed National Institutes of Health Clinical Center (CC) NA
NCT00004660 Randomized Study of Sequential Orbital Radiotherapy for Graves’ Ophthalmopathy https://ClinicalTrials.gov/show/NCT00004660 Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1998-01-31
NCT00001737 Cyclosporin Implant to Treat Uveitis https://ClinicalTrials.gov/show/NCT00001737 Completed National Institutes of Health Clinical Center (CC) NA
NCT00000145 Age-Related Eye Disease Study (AREDS) https://ClinicalTrials.gov/show/NCT00000145 Completed National Eye Institute (NEI) 2001-10-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04458012 Epidemiological Study of Dry Eye Disease in Stavanger: Dry Eye Disease in Patients Treated With Intravitreal Injections https://ClinicalTrials.gov/show/NCT04458012 Enrolling by invitation Helse Stavanger HF 2023-06-25
NCT03396042 Natural History Study of CEP290-Related Retinal Degeneration https://ClinicalTrials.gov/show/NCT03396042 Recruiting Allergan 2020-12-31
NCT04391439 Heart Rhythm After Intravenous Methylprednisolone Administration https://ClinicalTrials.gov/show/NCT04391439 Completed Medical University of Warsaw 2020-02-20
NCT03367767 Age-Related Eye Disease Study 2 (AREDS2) 10-year Follow-On https://ClinicalTrials.gov/show/NCT03367767 Completed National Institutes of Health Clinical Center (CC) 2019-03-21
NCT03195296 T and B Cells in Graves’ Orbitopathy https://ClinicalTrials.gov/show/NCT03195296 Completed University of Pisa 2017-05-31
NCT03122847 Glucocorticoids and Bone in Graves’ Ophthalmopathy https://ClinicalTrials.gov/show/NCT03122847 Recruiting Aarhus University Hospital 2020-01-31
NCT03103607 Disappearance of Graves’ Orbitopathy https://ClinicalTrials.gov/show/NCT03103607 Completed University of Pisa 2014-12-31
NCT03076697 Smartphone Screening for Eye Diseases https://ClinicalTrials.gov/show/NCT03076697 Enrolling by invitation University of Michigan 2023-06-30
NCT02946879 Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65) https://ClinicalTrials.gov/show/NCT02946879 Recruiting MeiraGTx UK II Ltd 2023-04-30
NCT02821767 Natural History, Pathogenesis, and Outcome of Ocular Disorders https://ClinicalTrials.gov/show/NCT02821767 Recruiting National Institutes of Health Clinical Center (CC) 2026-07-01
NCT02811692 Study for Collection of Aflibercept Data in Routine Practice https://ClinicalTrials.gov/show/NCT02811692 Completed Bayer 2017-11-27
NCT02811536 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) https://ClinicalTrials.gov/show/NCT02811536 Recruiting University Hospital Inselspital, Berne 2020-12-31
NCT02771236 Clinical and Molecular Studies in Families With Inherited Eye Disease https://ClinicalTrials.gov/show/NCT02771236 Recruiting National Institutes of Health Clinical Center (CC) 2025-01-19
NCT02721992 Graves’ Orbitopathy and Hypercholesterolemia https://ClinicalTrials.gov/show/NCT02721992 Completed University of Pisa 2017-06-30
NCT02583152 New Imaging Technology to Assess Effect of Enzyme Replacment Therapy on Eye Disease Progession in Mucopolysacchardiosis https://ClinicalTrials.gov/show/NCT02583152 Recruiting Manchester Royal Eye Hospital 2020-11-30
NCT00655096 Screening for Research Participants https://ClinicalTrials.gov/show/NCT00655096 Recruiting National Institutes of Health Clinical Center (CC) NA
NCT02471287 Genetics of Inherited Eye Disease https://ClinicalTrials.gov/show/NCT02471287 Recruiting National Institutes of Health Clinical Center (CC) 2022-09-01
NCT02397109 mDixon TSE MRI Sequence And Conventional MRI Sequences In Dysimmune Orbitopathies (DDX) https://ClinicalTrials.gov/show/NCT02397109 Recruiting Fondation Ophtalmologique Adolphe de Rothschild 2020-10-31
NCT02332343 Sparing of the Fovea in Geographic Atrophy Progression https://ClinicalTrials.gov/show/NCT02332343 Completed University Hospital, Bonn 2017-01-31
NCT02317328 Adaptive Optics Retinal Imaging https://ClinicalTrials.gov/show/NCT02317328 Recruiting National Institutes of Health Clinical Center (CC) 2026-03-31
NCT02252744 Prevalence of Dry Eye Disease in Patients Diagnosed With Rheumatoid Arthritis https://ClinicalTrials.gov/show/NCT02252744 Completed Western University of Health Sciences 2014-06-30
NCT02111928 NovaTears® Eye Drops Observational Study https://ClinicalTrials.gov/show/NCT02111928 Completed Novaliq GmbH 2014-05-31
NCT02077894 Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions https://ClinicalTrials.gov/show/NCT02077894 Recruiting National Institutes of Health Clinical Center (CC) 2020-08-05
NCT02042820 Ocular Surface Immune Response in Dry Eye Disease https://ClinicalTrials.gov/show/NCT02042820 Completed Tufts Medical Center 2015-07-31
NCT01915238 Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study https://ClinicalTrials.gov/show/NCT01915238 Completed National Institutes of Health Clinical Center (CC) 2014-06-20
NCT01857440 The Flashing Light-Induced Pupil Response (FLIPR) Glaucoma Study https://ClinicalTrials.gov/show/NCT01857440 Completed Ohio State University 2014-12-31
NCT01600261 iCam Clinical Validation Study https://ClinicalTrials.gov/show/NCT01600261 Completed Optovue 2012-05-31
NCT01553474 Blood and Saliva Sample Collection for AREDS 2 https://ClinicalTrials.gov/show/NCT01553474 Completed National Institutes of Health Clinical Center (CC) NA
NCT01459731 Optical Coherence Tomography (OCT) Data Collection Study https://ClinicalTrials.gov/show/NCT01459731 Completed Optovue 2012-03-31
NCT01321424 Diurnal Variation in Tear Osmolarity https://ClinicalTrials.gov/show/NCT01321424 Completed Ophthalmic Consultants of Long Island 2016-02-29
NCT00594672 Age-Related Eye Disease Study (AREDS) Follow-Up https://ClinicalTrials.gov/show/NCT00594672 Active, not recruiting National Institutes of Health Clinical Center (CC) NA
NCT04433936 Corneal Tomographic Parameters in TGD https://ClinicalTrials.gov/show/NCT04433936 Completed Mansoura University 2018-06-01
NCT04416776 Validation of the Utility of Strabismus Intelligent Diagnostic System https://ClinicalTrials.gov/show/NCT04416776 Recruiting Sun Yat-sen University 2020-06-10
NCT04404803 Motivations and Barriers to Participating in Ophthalmology Research Projects https://ClinicalTrials.gov/show/NCT04404803 Recruiting Manchester University NHS Foundation Trust 2024-01-31
NCT04213430 Development and Validation of a Deep Learning System for Multiple Ocular Fundus Diseases Using Retinal Images https://ClinicalTrials.gov/show/NCT04213430 Recruiting Sun Yat-sen University 2020-02-29
NCT04166578 Analgetic Effect of Two Solutions of Intracameral Anesthesia During Cataract Surgery in Patients https://ClinicalTrials.gov/show/NCT04166578 Completed Medical University of Lublin 2017-06-30
NCT04101604 Biomarkers of Common Eye Diseases https://ClinicalTrials.gov/show/NCT04101604 Recruiting Sun Yat-sen University 2020-10-01
NCT04101591 Identification and Measurement of Antioxidants and Cytokines in the Anterior Chamber of Various Ocular Disorders https://ClinicalTrials.gov/show/NCT04101591 Recruiting Chang Gung Memorial Hospital 2020-01-15
NCT04053335 Smarter Care Virginia https://ClinicalTrials.gov/show/NCT04053335 Active, not recruiting University of California, Los Angeles 2021-08-31
NCT04043949 The Influences of Dry Eye Disease on Optical Quality https://ClinicalTrials.gov/show/NCT04043949 Completed Peking University Third Hospital 2018-07-01
NCT03899922 Monitoring Drug-induced Uveitis https://ClinicalTrials.gov/show/NCT03899922 Recruiting Groupe Hospitalier Pitie-Salpetriere 2020-04-01
NCT03665090 Shanghai Cohort Study of Diabetic Eye Disease https://ClinicalTrials.gov/show/NCT03665090 Enrolling by invitation Shanghai Eye Disease Prevention and Treatment Center 2018-12-31
NCT03590080 Impact of Intravenous Methylprednisolone Treatment on Blood Pressure https://ClinicalTrials.gov/show/NCT03590080 Completed Medical University of Warsaw 2015-12-30
NCT03587948 Shanghai Children and Adolescent Diabetes Eye Study https://ClinicalTrials.gov/show/NCT03587948 Recruiting Shanghai Eye Disease Prevention and Treatment Center 2028-01-01
NCT03535090 Coagulation After Intravenous Methylprednisolone Administration https://ClinicalTrials.gov/show/NCT03535090 Completed Medical University of Warsaw 2014-12-31
NCT03515863 Natural History and Risk Factors of TAO https://ClinicalTrials.gov/show/NCT03515863 Recruiting Sun Yat-sen University 2021-05-09
NCT03499145 Validation of the Utility of Ophthalmology Intelligent Diagnostic System https://ClinicalTrials.gov/show/NCT03499145 Completed Sun Yat-sen University 2019-08-31
NCT03498417 Anti-insulin-like Growth Factor-1 Receptor (IGF-1R) Antibodies in Graves’ Disease and Graves’ Orbitopathy https://ClinicalTrials.gov/show/NCT03498417 Completed University of Pisa 2018-07-20
NCT03492242 Immune CHeckpoint Inhibitors Monitoring of Adverse Drug ReAction https://ClinicalTrials.gov/show/NCT03492242 Completed Groupe Hospitalier Pitie-Salpetriere 2018-09-30
NCT03426696 Psychological Status and Related Factors of Thyroid Related Eye Disease https://ClinicalTrials.gov/show/NCT03426696 Completed Sun Yat-sen University 2018-12-01
NCT01240343 Creation of the Biobank Related to Eye Disease https://ClinicalTrials.gov/show/NCT01240343 Completed William Beaumont Hospitals 2017-12-04
NCT00953693 Patient Specific Induced Pluripotency Stem Cells (PSiPS) https://ClinicalTrials.gov/show/NCT00953693 Completed Royan Institute 2010-01-31
NCT00848198 TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease https://ClinicalTrials.gov/show/NCT00848198 Completed TearLab Corporation 2011-03-31
NCT00827255 Physician’s Evaluation of Cyclosporine Ophthalmic Emulsion 0.05% https://ClinicalTrials.gov/show/NCT00827255 Completed Allergan 2009-06-30
NCT00811512 Fundus Changes in the Microphthalmy Eyes https://ClinicalTrials.gov/show/NCT00811512 Completed Hospital de Olhos Sadalla Amin Ghanem 2008-09-30
NCT04127006 Rate of Progression in EYS Related Retinal Degeneration https://ClinicalTrials.gov/show/NCT04127006 Recruiting Jaeb Center for Health Research 2024-01-31
NCT01432847 Cell Collection to Study Eye Diseases https://ClinicalTrials.gov/show/NCT01432847 Recruiting National Institutes of Health Clinical Center (CC) NA
NCT03324022 Observing the Relationship of Fibroblast Growth Factor and Fibroblast in Thyroid Eye Disease https://ClinicalTrials.gov/show/NCT03324022 Recruiting National Taiwan University Hospital 2017-12-25
NCT00708955 Evaluation and Treatment of People With Eye Diseases https://ClinicalTrials.gov/show/NCT00708955 Completed National Institutes of Health Clinical Center (CC) NA
NCT00697528 Color Doppler Imaging of Orbital Venous Flow in Grave’s Orbitopathy https://ClinicalTrials.gov/show/NCT00697528 Completed University of Sao Paulo 2008-12-31
NCT00678860 Validation of Computerized Vision-Targeted Quality-of-Life Questionnaires https://ClinicalTrials.gov/show/NCT00678860 Completed National Institutes of Health Clinical Center (CC) NA
NCT00553579 The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects https://ClinicalTrials.gov/show/NCT00553579 Completed Southern California College of Optometry 2008-05-31
NCT00473278 Analysis of Human Tear Proteins in Children https://ClinicalTrials.gov/show/NCT00473278 Completed University of Colorado, Denver 2009-06-30
NCT00357071 Immune Responses to Antigens in Non-infectious Eye Inflammatory Diseases https://ClinicalTrials.gov/show/NCT00357071 Completed National Institutes of Health Clinical Center (CC) NA
NCT00342810 Analyses of Existing Framingham Data https://ClinicalTrials.gov/show/NCT00342810 Completed National Institutes of Health Clinical Center (CC) NA
NCT00116090 Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study https://ClinicalTrials.gov/show/NCT00116090 Completed National Institutes of Health Clinical Center (CC) NA
NCT00106756 Clinical and Genetic Studies of Familial Exudative Vitreoretinopathy https://ClinicalTrials.gov/show/NCT00106756 Completed National Institutes of Health Clinical Center (CC) 2006-11-01
NCT00088348 Screening for Research Subjects With Anterior Segment Diseases https://ClinicalTrials.gov/show/NCT00088348 Completed National Institutes of Health Clinical Center (CC) NA
NCT00078299 Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System https://ClinicalTrials.gov/show/NCT00078299 Completed National Institutes of Health Clinical Center (CC) NA
NCT00076271 Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases https://ClinicalTrials.gov/show/NCT00076271 Completed National Institutes of Health Clinical Center (CC) NA
NCT00073099 Digital Photography to Evaluate Dry Eye https://ClinicalTrials.gov/show/NCT00073099 Completed National Institutes of Health Clinical Center (CC) NA
NCT00809003 Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease https://ClinicalTrials.gov/show/NCT00809003 Completed University of Waterloo NA
NCT00011817 Evaluation and Treatment of Patients With Inherited Eye Diseases https://ClinicalTrials.gov/show/NCT00011817 Completed National Institutes of Health Clinical Center (CC) NA
NCT00559234 Potential Research Participants for Future Studies of Inherited Eye Diseases https://ClinicalTrials.gov/show/NCT00559234 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001732 Screening for Studies on Inherited Eye Diseases https://ClinicalTrials.gov/show/NCT00001732 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001224 Analysis of Eye Tissue https://ClinicalTrials.gov/show/NCT00001224 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02500862 Characterization of Potential Biomarkers of Eye Disease and Vision https://ClinicalTrials.gov/show/NCT02500862 Active, not recruiting Association for Innovation and Biomedical Research on Light and Image 2019-12-31
NCT02485847 IRIS Registry: Intelligent Research in Sight Registry https://ClinicalTrials.gov/show/NCT02485847 Recruiting American Academy of Ophthalmology 2100-01-31
NCT02435940 Inherited Retinal Degenerative Disease Registry https://ClinicalTrials.gov/show/NCT02435940 Recruiting Foundation Fighting Blindness 2037-06-30
NCT04302220 Myopic Optic Neuropathy in Chinese High Myopia Population https://ClinicalTrials.gov/show/NCT04302220 Recruiting Sun Yat-sen University 2023-03-31
NCT03652415 DRy Eye Outcome and Prescription Study https://ClinicalTrials.gov/show/NCT03652415 Recruiting Guy’s and St Thomas’ NHS Foundation Trust 2021-08-23
NCT03611387 Artificial Intelligence Screening on Patients With Primary Angle Closure Glaucoma https://ClinicalTrials.gov/show/NCT03611387 Recruiting Sun Yat-sen University 2019-12-31